Ari Gold tries to save his marriage by hosting a birthday party for his wife, Eric Murphy gets a request from Terrance McQuewick, and Vincent Chase has more issues with his girlfriend and porn star, Sasha Grey and with Vince's drug problems becoming increasingly big, Turtle, Drama, Scott Lavin, E and Ari stage an intervention but it may be a case of too little, too late.
- Scott Lavin reveals that he's planning on taking down Murray Berenson.
- After some disagreement, E eventually relents and agrees to join Scott in taking down Murray.
- Vince is presumably arrested after a police officer finds a bag of cocaine in Vince's belongings.
- Adrian Grenier as Vincent Chase
- Kevin Dillon as Johnny 'Drama' Chase
- Kevin Connolly as Eric Murphy
- Jeremy Piven as Ari Gold
- Jerry Ferrara as Turtle
- Scott Caan as Scott Lavin.
- Christina Aguilera as herself
- Drew Brees as himself
- John Cleese as himself
- Mark Cuban as himself
- Eminem as himself
- Jordan Farmar as himself
- Sasha Grey as herself
- Ryan Howard as himself
- Minka Kelly as herself
- Kevin Love as himself
- Paul Rosenberg as himself
- The Alchemist as himself
- Mr. Porter as himself
- Royce da 5'9" as himself